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Hydrogen-Bonded Dendronized Polymers and Their Self-Assembly in Solution
Xie D (谢荡), Jiang M (江明), Zhang GZ (张广照), Chen DY (陈道勇) |
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Frechet-type benzyl ether dendrons of second and third generations with a carboxyl group (G2, G3) at the apex site could attach to poly(4-vinylpyridine) (PVP), forming hydrogen-bonded dendronized polymers (HB denpols) in their common solvent, chloroform.  The HB denpols show unique self-assembly behavior, forming vesicles in the common solvent under ultrasonic treatment.The structure and morphologyof the vesicles were characterized by dynamic light scattering
(DLS), static light scattering(SLS), SEM, TEM,and AFM. The size of the vesicles decreases and thethickness of the vascular membrane increases as the molar ratio of Gx/PVP increases. The hydrogen bonding, pi-pi aromatic stacking of the dendrons, and the considerable difference in architecture between the dendron Gx and PVP are themain factors facilitating the assembly of the HB denpols in the common solvent.
Xie D, Jiang M, Zhang GZ, et al.
Chemistry-A European Journal 13 (12) 3346
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One-Pot Synthesis of Amphiphilic Polymeric Janus Particles and Their Self-Assembly into Supermicelles with a Narrow Size Distribution
Nie L (聂磊), Liu SY (刘世勇), Shen WM (沈文明), Chen DY (陈道勇), Jiang M (江明)
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Nie L, Liu SY, Shen WM, et al. Angew.Chem.Int.Ed 46 (33) 6321 |
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Self-assembly of beta-casein and lysozyme
Pan, XY (潘晓贇); Yu, SY (俞绍勇); Yao, P, et al. |
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Abstract
The self-assembly of β-casein and lysozyme, a linear and a globular protein with isoelectric point of pH 5.0 and 10.7, respectively, was studied. Polydisperse electrostatic complex micelles formed when mixing β-casein and lysozyme aqueous solutions. After the micelle solution was heated, lysozyme ge lated and β-casein was trapped in the gel, producing narrowly dispersed nanoparticles. The nanoparticles were characterized with laser light scattering, ζ-potential, steady state fluorescence, atomic force microscopy, and transmission electron microscopy. The nanoparticles have spherical shape and their sizes depend on the pH of the heat treatment and the molar ratio of β-casein to lysozyme. The nanoparticles display amphoteric property and are relatively hydrophobic at pH around 5 and around 10. The net charges on the surface stabilize the nanoparticles in the solution.
Pan, XY; Yu, SY; Yao, P, et al. J. Colloid Interface Sci. 2007, 316 (2), 405
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Micellization induced by the inclusion
complexation between β-CD and adamantly group (ADA)
Jing Wang (王竞), Ming Jiang* (江明) |
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We developed a new route to fabricate non-covalently connected
micelles (NCCM) of PGMA-CD/PtBA-ADA in aqueous media based on
host-guest intera ction
of β-CD and ADA. The presence of the β-CD cavities in the micellar
shell provides broad opportunities to modify the micellar surface to
meet different requirements in applications. Via shell-crosslinking
and core-removal of the micelles, hollow spheres composed of
β-CD-containing polymers were also obtained. These follow spheres
possess multi-scale holes i.e. the large central one in size of 102
nm and many small β-CD cavities in 0.7 nm.
Wang J, Jiang M J. Am. Chem. Soc. 2006, 128, 3703
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pH-Dependent Self-Assembly: Micellization and
Micelle–Hollow-Sphere Transition of Cellulose-Based Copolymers
Hongjing Dou (窦红静), Ming Jiang* (江明) |
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The micellization of HEC-graft-poly(acrylic acid) (HEC-g-PAA),driven
by the complexation between PAA grafts and HEC chains, and
the transition between micelles and hollow spheres of in
water were found to be pH-dependent and reversible.
Hongjing Dou,
Ming Jiang, Huisheng Peng, et al.
Angew.Chem.Int.Ed.,2003,42,1516 |
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A Novel Route to Thermo-Sensitive
Polymeric Core-shell Aggregates and Hollow Spheres in
Aqueous Media
Youwei Zhang (张幼维), Ming Jiang* (江明) |
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The Poly(ε-carprolactone)(PCL)/Poly(N-isopropylacrylamide)(PNIPAM)
core-shell particles was obtained by localizing the
polymerization of NIPAM and crosslinker  methylene
bisacrylamide around the surface of the PCL
nanoparticles. The resultant particles were
converted to hollow spheres by simply degradating
the PCL core with enzyme. The attained hollow
spheres is thermo-sensitive and displays reversible
swelling and de-swelling around 32℃. Youwei Zhang, Jiang Ming et.al. Adv.Funct.Mater. 2005,15,695 |
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Optical Switching of Self-Assembly:
Micellization and Micelle–Hollow Sphere Transition of
Hydrogen-Bonded Polymers
Xikui Liu (刘习奎), Ming Jiang*(江明) |
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The work reports reversible optical switching of
micellization and micelle-hollow sphere transition in a
blend solution of poly(4-phenylazomaleinanil- co-4-vinyl
pyridine) (AzoMI-VPy) and carboxyl-ended polybutadiene CPB.
Under UV irradiation, the trans-azobenzene units transformed
into polar cis conformation and made AzoMI-VPy insoluble.
Thus micelles formed with (AzoMI-VPy) core stabilized CPB
shell through interpolymer hydrogen bonding. Upon visible
light irradiation, the micelles quickly disassociated due to
the cis form returning to  trans
form. After core crosslinking, the micelles showed a
reversible morphology change responding to light
irradiation: visible light caused the formation of hollow
spheres due to the core dissociation as a result of cis
azobenzene turning to trans while UV light made the hollow
spheres return to micelles due to the isomerization in the
opposite direction.
Xikui Liu, Ming Jiang Angew.Chem.Int.Ed 2006, 45, 3846
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One-Pot Synthesis of Amphiphilic Polymeric Janus Particles and Their Self-Assembly into Supermicelles with a Narrow Size Distribution
Nie L (聂磊), Liu SY (刘世勇), Shen WM (沈文明), Chen DY (陈道勇), Jiang M (江明)
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Nie L, Liu SY, Shen WM, et al. Angew.Chem.Int.Ed 46 (33) 6321 |
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Preparation of Core-Stabilized Polymeric
Micelles with a Mixed Shell Formed by Two Incompatible Polymers
Taoran Hui (惠陶然), Daoyong Chen* (陈道勇), Ming Jiang |
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The preparation of core-stabilized micelles with PEO/PS as th  e
shell by directly cross-linking P2VP in PS-b-P2VP and PEO-b-P2VP
mixture in DMF, which is the common solvent of the block copolymers,
using 1,4-dibromobutane as the cross-linker. Although the PEO chains
and the PS chains are strongly incompatible, the cross-linking of
P2VP blocks connects both the PEO and the PS chains to a common core
and enables the sufficient mixing of the unlike blocks in the shell.
Taoran Hui, Daoyong
Chen et.al. Macromolecule.2005,38,5834 |
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Short-life core-shell structured nano-aggregates
formed by the self-assembly of PEO-b-PAA/ETC
(1-(3-dimethylaminopropyl) -3-ethylcarbodiimide methiodide) and
their stabilization
Chunfeng Gu (顾春锋), Daoyong Chen* (陈道勇), Ming Jiang |
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 The
self-association takes place in the aqueous solution of
PEO-b-PAA/ETC at the early stage of the reaction between PAA and
ETC. Due to the reaction cycle of ETC with PAA (as indicated in the
scheme), the aggregates have a limited life in water. After staying
unchanged for several days in the aqueous solutions, the aggregates
dissociate and finally disappear 1 to 3 weeks after their formation.
Chunfeng Gu,
Daoyong Chen et.al. Macromolecule.2004,37,1666 |
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Self-assembly of ovalbumin and lysozyme.
Shaoyong Yu, Ping Yao* |
Shaoyong Yu, Ping Yao*. Biopolymers 2006, 83: 148–158
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Self-assembly of ibuprofen and BSA-dextran conjugates leading to effective loading of the drug
Juan Li and Ping Yao* |
Juan Li and Ping Yao*. Langmuir 2009, 25(11): 6385–6391
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Sustained and extended release with structural and activity recovery of lysozyme from complexes with sodium (sulfamate-carboxylate)isoprene/ethylene oxide block copolymer
Gao Gao, Yunfeng Yan, Stergios Pispas, Ping Yao* |
Gao Gao, Yunfeng Yan, Stergios Pispas, Ping Yao*.Macromolecular Bioscience 2009, DOI: 10.1002/mabi.200900186
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Reversibility of Structural Transition of Cytochrome c on Interacting with and Releasing from Alternating Copolymers of Maleic Acid and Alkene
Li Liang, Ping Yao*, Ming Jiang |
Li Liang, Ping Yao*, Ming Jiang. Biomacromolecules 2006, 7(6): 1829-1835.
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Self-assembly Based on Biomacromolecules
Shaoyong Yu (喻绍勇), Xiaoyun Pan (潘晓赟), Ping Yao*, Ming Jiang |
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A new method was developed to produce nanogels with
oppositely charged protein pairs or protein-polysaccharide pairs,
such as chitosan-ovalbumin and ovalbumin-lysozyme pairs. The na nogels
have core-shell structure. The dispersibility, the size and the
hydrophobicity / hydrophilicity of the nanogels are pH responsible.
Left figure is an illustration of the charge change of
ovalbumin-lysozyme nanogels at different pH.Casein-g-dextran
copolymer was prepared through the Maillard reaction. The copolymers
form micelles at the pI of casein and the micelles dissociate when
pH is away from t he
pI. β-carotene can induce the copolymer micellization through
hydrophobic interactions during the β-carotene encapsulation
procedure.
Shaoyong Yu, Xiaoyun Pan,Ping Yao, Ming Jiang Langmuir 2006, 22, 2754
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Interactions of Apo Cytochrome c with
Alternating Copolymers of Maleic Acid and Alkene
Li Liang(梁丽), Ping Yao*, Ming Jiang |
The interactions of apo cytochrome c (apo cyt c) with
poly(isobutylene-alt-maleic acid) (PIMA) and
poly(1-tetradecene-alt-maleic acid) (PTMA) lead to apo cyt c a conformational change from random coil to -helical
structure. The -helix content is influenced by the copolymer
concentration, the length of alkyl chain of the copolymers, and
media pH. The interactions of PIMA or PTMA with apo cyt c at neutral
and alkali pH destroy the hydrophobic aggregation of PTMA or apo cyt
c and form new complex particles.
Li
Liang, Ping Yao, et.al. Langmuir.2004,20,3333 |
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